Dororo, a young orphan thief, meets Hyakkimaru, a strong ronin. Hyakkimaru’s father, a greedy seigneur , had made a pact with 12 demons, offering his yet-unborn son’s body parts in exchange for nice power. Thus, Hyakkimaru – who was born without arms, legs, eyes, ears, a nose or a mouth – was abandoned during a river as a baby. Rescued and raised by Dr. Honma, who equips him with artificial limbs and teaches him sword-fighting techniques, Hyakkimaru discovers that every time he slays a demon, a bit of his body is restored. Now, he roams the war-torn countryside in search of demons.